Unravelling the induction and development of intramembranous bones in the chicken eye

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dc.contributor.advisor Franz-Odendaal, Tamara
dc.creator Duench, Kellie
dc.date.accessioned 2011-09-23T16:38:42Z
dc.date.available 2011-09-23T16:38:42Z
dc.date.issued 2010
dc.identifier.other QP88.2 D84 2010
dc.identifier.uri http://library2.smu.ca/xmlui/handle/01/23726
dc.description x, 96 leaves : ill. ; 29 cm. en_CA
dc.description Includes abstract.
dc.description Includes bibliographical references (leaves 79-83).
dc.description.abstract Bone development is a complex process, involving multiple tissues and hierarchical inductive interactions. The study of skeletal development has focused on endochondral bones while intramembranous bones (e.g. scleral ossicles) have received less attention. Although, sonic hedgehog was recently demonstrated to be present during induction of scleral ossicles, other signalling molecules are still unknown. Using in situ hybridization and bead implantation I have demonstrated the presence or absence and the involvement of candidate genes and gene families during the development of scleral ossicles. Scleraxis, patched, as well as the bone morphogenetic protein (BMP) family of genes, were found to be involved in the development of scleral ossicles. Conversely, it was determined that indian hedgehog and msx2 are not present. This study has contributed to unravelling the signals involved during the induction and subsequent development of scleral ossicles and has contributed to the current understanding of intramembranous bone development. en_CA
dc.description.provenance Submitted by Dianne MacPhee (dianne.macphee@smu.ca) on 2011-09-23T16:38:42Z No. of bitstreams: 0 en
dc.description.provenance Made available in DSpace on 2011-09-23T16:38:42Z (GMT). No. of bitstreams: 0 Previous issue date: 2010 en
dc.language.iso en en_CA
dc.publisher Halifax, N.S. : Saint Mary's University en_CA
dc.subject.lcc QP88.2
dc.subject.lcsh Bones -- Growth -- Molecular aspects
dc.subject.lcsh Chickens -- Embryos
dc.subject.lcsh Eye -- Growth
dc.subject.lcsh Gene expression
dc.title Unravelling the induction and development of intramembranous bones in the chicken eye en_CA
dc.type Text en_CA
thesis.degree.name Master of Science in Applied Science
thesis.degree.level Masters
thesis.degree.discipline Biology
thesis.degree.grantor Saint Mary's University (Halifax, N.S.)
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